Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35568 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 24 RKVGYLRKPKSMHKRFFVLRA CK2_group 8349691
LTP
1.00
- PH
0.26
1QQG 44.26%
S 24 RKVGYLRKPKSMHKRFFVLRA PLK1 15849359
LTP
1.00
- PH
0.26
1QQG 44.26%
Y 46 SEAGGPARLEYYENEKKWRHK - 15592455
HTP
1.00
- PH
0.49
1QQG 9.61%
Y 46 SEAGGPARLEYYENEKKWRHK - 18083107
HTP
1.00
- PH
0.49
1QQG 9.61%
S 268 RAMSDEFRPRSKSQSSSNCSN IKK_group 12351658
LTP
1.00
- -
0.69
--
S 270 MSDEFRPRSKSQSSSNCSNPI IKK_group 12351658
LTP
1.00
YWHAG 14-3-3;
YWHAZ 14-3-3
-
0.69
--
S 272 DEFRPRSKSQSSSNCSNPISV IKK_group 12351658
LTP
1.00
- -
0.67
--
S 274 FRPRSKSQSSSNCSNPISVPL IKK_group 12351658
LTP
1.00
- -
0.69
--
S 307 VGLTRRSRTESITATSPASMV IKK_group 12351658
LTP
1.00
- -
0.78
--
S 307 VGLTRRSRTESITATSPASMV PKC_delta 14583092
LTP
1.00
- -
0.78
--
S 307 VGLTRRSRTESITATSPASMV - 16099428
LTP
1.00
- -
0.78
--
S 307 VGLTRRSRTESITATSPASMV - 15199052
LTP
1.00
- -
0.78
--
S 307 VGLTRRSRTESITATSPASMV - 16129690
LTP
1.00
- -
0.78
--
S 312 RSRTESITATSPASMVGGKPG IKK_group 12351658
LTP
1.00
- -
0.80
--
S 312 RSRTESITATSPASMVGGKPG - 11606564
LTP
1.00
- -
0.80
--
S 312 RSRTESITATSPASMVGGKPG - 15199052
LTP
1.00
- -
0.80
--
S 323 PASMVGGKPGSFRVRASSDGE PKC_zeta 15516986
LTP
0.05
- -
0.79
--
S 323 PASMVGGKPGSFRVRASSDGE - 14583092
LTP
0.05
- -
0.79
--
S 323 PASMVGGKPGSFRVRASSDGE PKC_zeta 16129678
LTP
0.05
- -
0.79
--
S 341 DGEGTMSRPASVDGSPVSPST IKK_group 12351658
LTP
0.96
- -
0.90
--
S 345 TMSRPASVDGSPVSPSTNRTH IKK_group 12351658
LTP
1.00
- -
0.90
--
S 348 RPASVDGSPVSPSTNRTHAHR - 16020478
LTP
1.00
- -
0.90
--
S 348 RPASVDGSPVSPSTNRTHAHR - 18220336
HTP
1.00
- -
0.90
--
S 374 RLHPPLNHSRSIPMPASRCSP - 16020478
LTP
1.00
YWHAG 14-3-3;
YWHAZ 14-3-3
-
0.77
--
S 527 LDNRFRKRTHSAGTSPTITHQ IKK_group 12351658
LTP
1.00
- -
0.82
--
T 530 RFRKRTHSAGTSPTITHQKTP - 16020478
LTP
1.00
- -
0.88
--
S 531 FRKRTHSAGTSPTITHQKTPS IKK_group 12351658
LTP
1.00
- -
0.89
--
S 531 FRKRTHSAGTSPTITHQKTPS - 18220336
HTP
1.00
- -
0.89
--
S 574 SGGRLPGHRHSAFVPTRSYPE PKC_delta 15516986
LTP
1.00
- -
0.80
--
S 574 SGGRLPGHRHSAFVPTRSYPE - 14583092
LTP
1.00
- -
0.80
--
Y 612 DSSTLHTDDGYMPMSPGVAPV - 15001544
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.81
--
Y 612 DSSTLHTDDGYMPMSPGVAPV - 18083107
HTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.81
--
S 616 LHTDDGYMPMSPGVAPVPSGR MAPK3 15001544
LTP
0.18
MOD_ProDKin_1
- -
0.82
--
S 616 LHTDDGYMPMSPGVAPVPSGR - 14769130
LTP
0.18
MOD_ProDKin_1
- -
0.82
--
S 629 VAPVPSGRKGSGDYMPMSPKS - 17081983
HTP
0.30
- -
0.82
--
Y 632 VPSGRKGSGDYMPMSPKSVSA - 15001544
LTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.83
--
Y 632 VPSGRKGSGDYMPMSPKSVSA - 18083107
HTP
1.00
PIK3R1 SH2;
PIK3R2 SH2
-
0.83
--
S 636 RKGSGDYMPMSPKSVSAPQQI - 14769130
LTP
1.00
- -
0.79
--
S 636 RKGSGDYMPMSPKSVSAPQQI - 16099428
LTP
1.00
- -
0.79
--
S 636 RKGSGDYMPMSPKSVSAPQQI - 15576463
LTP
1.00
- -
0.79
--
S 636 RKGSGDYMPMSPKSVSAPQQI - 16123357
LTP
1.00
- -
0.79
--
S 636 RKGSGDYMPMSPKSVSAPQQI - 17081983
HTP
1.00
- -
0.79
--
S 639 SGDYMPMSPKSVSAPQQIINP - 14769130
LTP
1.00
- -
0.73
--
S 639 SGDYMPMSPKSVSAPQQIINP - 16099428
LTP
1.00
- -
0.73
--
S 639 SGDYMPMSPKSVSAPQQIINP - 15576463
LTP
1.00
- -
0.73
--
S 639 SGDYMPMSPKSVSAPQQIINP - 16123357
LTP
1.00
- -
0.73
--
Y 662 RHPQRVDPNGYMMMSPSGGCS - 15592455
HTP
1.00
Fyn SH2;
MATK SH2;
PIK3R1 SH2;
PTPN11 SH2
-
0.77
--
S 794 ARHQHLRLSTSSGRLLYAATA SIK 12624099
LTP
1.00
- -
0.65
--
S 794 ARHQHLRLSTSSGRLLYAATA AMPK_group 20135346
LTP
1.00
- -
0.65
--
S 892 QPLLHPPEPKSPGEYVNIEFG - 16020478
LTP
1.00
- -
0.79
--
Y 896 HPPEPKSPGEYVNIEFGSDQS - 11259577
LTP
1.00
GRB2 SH2;
PTPN11 SH2
-
0.76
--
S 1078 GMSAFTRVNLSPNRNQSAKVI - 16503154
LTP
0.30
- -
0.60
--
S 1101 DPQGCRRRHSSETFSSTPSAT PKC_theta 15364919
LTP
1.00
- -
0.78
--
S 1101 DPQGCRRRHSSETFSSTPSAT - 17081983
HTP
1.00
- -
0.78
--
S 1101 DPQGCRRRHSSETFSSTPSAT RSK-1 17709744
LTP
1.00
- -
0.78
--
S 1101 DPQGCRRRHSSETFSSTPSAT - 18220336
HTP
1.00
- -
0.78
--
T 1111 SETFSSTPSATRVGNTVPFGA - 18220336
HTP
1.00
- -
0.68
--
S 1145 SEDVKRHSSASFENVWLRPGE - 16020478
LTP
1.00
- -
0.61
--
S 1222 GSGESSSTRRSSEDLSAYASI - 16020478
LTP
0.07
- -
0.70
--
S 1223 SGESSSTRRSSEDLSAYASIS - 16020478
LTP
0.11
- -
0.68
--

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35569 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 3         MASPPDTDGFSDV - 17242355
HTP
- - -
0.50
--
S 267 DEFRPRSKSQSSSSCSNPISV - 12714600
LTP
1.00
- -
0.66
--
S 302 VGLTRRSRTESITATSPASMV PKB_group 11701324
LTP
1.00
MOD_PKB_1
- -
0.78
--
S 307 RSRTESITATSPASMVGGKPG - 16055440
LTP
1.00
- -
0.80
--
S 307 RSRTESITATSPASMVGGKPG - 15994203
LTP
1.00
- -
0.80
--
S 307 RSRTESITATSPASMVGGKPG - 12714600
LTP
1.00
- -
0.80
--
S 307 RSRTESITATSPASMVGGKPG - 14998989
LTP
1.00
- -
0.80
--
S 307 RSRTESITATSPASMVGGKPG - 11160134
LTP
1.00
- -
0.80
--
S 307 RSRTESITATSPASMVGGKPG - 15314024
LTP
1.00
- -
0.80
--
S 318 PASMVGGKPGSFRVRASSDGE PKC_group 16129678
LTP
0.05
- -
0.79
--
S 318 PASMVGGKPGSFRVRASSDGE PKC_group 16099431
LTP
0.05
- -
0.79
--
S 318 PASMVGGKPGSFRVRASSDGE PKC_group 16055440
LTP
0.05
- -
0.79
--
S 324 GKPGSFRVRASSDGEGTMSRP - 17242355
HTP
1.00
- -
0.83
--
S 340 TMSRPASVDGSPVSPSTNRTH - 17242355
HTP
1.00
- -
0.90
--
S 408 TSDCLFPRRSSASVSGSPSDG - 15485932
LTP
1.00
- -
0.60
--
Y 608 DTSNLHTDDGYMPMSPGVAPV - 9395471
LTP
1.00
PIK3R1 SH2 -
0.80
--
Y 608 DTSNLHTDDGYMPMSPGVAPV - 15821749
LTP
1.00
PIK3R1 SH2 -
0.80
--
S 612 LHTDDGYMPMSPGVAPVPSNR - 15994203
LTP
0.18
- -
0.81
--
S 612 LHTDDGYMPMSPGVAPVPSNR - 9395471
LTP
0.18
- -
0.81
--
S 612 LHTDDGYMPMSPGVAPVPSNR - 15821749
LTP
0.18
- -
0.81
--
S 612 LHTDDGYMPMSPGVAPVPSNR - 10092613
LTP
0.18
- -
0.81
--
S 632 RKGNGDYMPMSPKSVSAPQQI ROCK2 16098829
LTP
1.00
- -
0.79
--
S 632 RKGNGDYMPMSPKSVSAPQQI - 11287630
LTP
1.00
- -
0.79
--
S 635 NGDYMPMSPKSVSAPQQIINP ROCK2 16098829
LTP
1.00
- -
0.72
--
S 635 NGDYMPMSPKSVSAPQQIINP - 11287630
LTP
1.00
- -
0.72
--
S 635 NGDYMPMSPKSVSAPQQIINP - 15994203
LTP
1.00
- -
0.72
--
S 789 ARHQHLRLSSSSGRLRYTATA AMPK_group 11598104
LTP
0.03
- -
0.75
--
S 1097 DTQGCRRRHSSETFSAPTRAG - 15364919
LTP
1.00
- -
0.79
--
S 1139 SEDVKRHSSASFENVWLRPGD - 17242355
HTP
1.00
- -
0.64
--
S 1214 SNEGNSPRRSSEDLSNYASIS - 17242355
HTP
1.00
- -
0.76
--

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35570 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
GO-Terms:
[show]
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 99 RDEHFAIAADSEAEQDSWYQA CK2_group 8349691
LTP
0.11
MOD_CK2_1
- PH
0.28
- medium
Y 460 PARGEEELSNYICMGGKGAST INSR 7504175
LTP
1.00
- -
0.58
- medium
T 502 GATMGTSPALTGDEAAGAADL CK2_group 8349691
LTP
0.00
MOD_CK2_1
- -
0.72
- medium
Y 608 DSSNLHTDDGYMPMSPGVAPV INSR 7504175
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 608 DSSNLHTDDGYMPMSPGVAPV - 12220227
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 608 DSSNLHTDDGYMPMSPGVAPV IGF1R 11572799
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 608 DSSNLHTDDGYMPMSPGVAPV INSR 11572799
LTP
1.00
PIK3R1 SH2 -
0.79
- medium
Y 628 VPSNRKGNGDYMPMSPKSVSA INSR 7504175
LTP
1.00
PIK3R1 SH2 -
0.81
- medium
Y 628 VPSNRKGNGDYMPMSPKSVSA IGF1R 11572799
LTP
1.00
PIK3R1 SH2 -
0.81
- medium
Y 628 VPSNRKGNGDYMPMSPKSVSA INSR 11572799
LTP
1.00
PIK3R1 SH2 -
0.81
- medium
Y 658 RHPQRVDPNGYMMMSPSGSCS IGF1R 11572799
LTP
1.00
- -
0.72
- medium
Y 727 GGKLLPCTGDYMNMSPVGDSN IGF1R 11572799
LTP
1.00
- -
0.60
- medium
S 789 ARHQHLRLSSSSGRLRYTATA AMPK_group 11598104
LTP
0.03
- -
0.77
- medium
Y 895 HPPEPKSPGEYVNIEFGSGQP INSR 7504175
LTP
1.00
GRB2 SH2 -
0.80
- medium
Y 895 HPPEPKSPGEYVNIEFGSGQP IGF1R 8530377
LTP
1.00
GRB2 SH2 -
0.80
- medium
Y 895 HPPEPKSPGEYVNIEFGSGQP INSR 8530377
LTP
1.00
GRB2 SH2 -
0.80
- medium
Y 939 APREETGSEEYMNMDLGPGRR INSR 7504175
LTP
1.00
PIK3R1 SH2 -
0.87
- medium
Y 939 APREETGSEEYMNMDLGPGRR IGF1R 11572799
LTP
1.00
PIK3R1 SH2 -
0.87
- medium
Y 939 APREETGSEEYMNMDLGPGRR INSR 11572799
LTP
1.00
PIK3R1 SH2 -
0.87
- medium
Y 987 TRSVPNSRGDYMTMQIGCPRQ INSR 7504175
LTP
0.16
- -
0.64
- medium
Y 987 TRSVPNSRGDYMTMQIGCPRQ IGF1R 11572799
LTP
0.16
- -
0.64
- medium
Y 987 TRSVPNSRGDYMTMQIGCPRQ INSR 11572799
LTP
0.16
- -
0.64
- medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK INSR 7504175
LTP
1.00
PTPN11 SH2 -
0.48
- medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK IGF1R 11572799
LTP
1.00
PTPN11 SH2 -
0.48
- medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK INSR 11572799
LTP
1.00
PTPN11 SH2 -
0.48
- medium
Y 1222 PRRSSEDLSTYASINFQKQPE INSR 7504175
LTP
0.09
PTPN11 SH2 -
0.77
- medium
Y 1222 PRRSSEDLSTYASINFQKQPE - 12220227
LTP
0.09
PTPN11 SH2 -
0.77
- medium

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