Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35568 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-19010   INSR_HUMAN
MINT-68735   P85A_HUMAN
MINT-74551   EGFR_HUMAN
MINT-74553   ERBB2_HUMAN
MINT-3975430   1433S_HUMAN
MINT-6628637   LT_SV40
MINT-6793745   PTN1_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
protein kinase C binding,
insulin-like growth factor receptor binding,
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity,
SH2 domain binding		 microsome,
caveola,
cytosol,
insulin receptor complex,
nucleus		 negative regulation of insulin receptor signaling pathway,
glucose homeostasis,
positive regulation of insulin receptor signaling pathway,
positive regulation of fatty acid beta-oxidation,
phosphoinositide 3-kinase cascade,
negative regulation of insulin secretion,
positive regulation of glycogen biosynthetic process,
insulin receptor signaling pathway,
positive regulation of glucose import,
positive regulation of phosphoinositide 3-kinase activity
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 24 RKVGYLRKPKSMHKRFFVLRA CK2_group 8349691
LTP
1.00
 - PH
0.26
 1QQG 44.26%
S 24 RKVGYLRKPKSMHKRFFVLRA PLK1 15849359
LTP
1.00
 - PH
0.26
 1QQG 44.26%
Y 46 SEAGGPARLEYYENEKKWRHK - 15592455
HTP
1.00
 - PH
0.49
 1QQG 9.61%
Y 46 SEAGGPARLEYYENEKKWRHK - 18083107
HTP
1.00
 - PH
0.49
 1QQG 9.61%
S 268 RAMSDEFRPRSKSQSSSNCSN IKK_group 12351658
LTP
1.00
 - -
0.69
 --
S 270 MSDEFRPRSKSQSSSNCSNPI IKK_group 12351658
LTP
1.00
 YWHAG 14-3-3;
YWHAZ 14-3-3		 -
0.69
 --
S 272 DEFRPRSKSQSSSNCSNPISV IKK_group 12351658
LTP
1.00
 - -
0.67
 --
S 274 FRPRSKSQSSSNCSNPISVPL IKK_group 12351658
LTP
1.00
 - -
0.69
 --
S 307 VGLTRRSRTESITATSPASMV IKK_group 12351658
LTP
1.00
 - -
0.78
 --
S 307 VGLTRRSRTESITATSPASMV PKC_delta 14583092
LTP
1.00
 - -
0.78
 --
S 307 VGLTRRSRTESITATSPASMV - 16099428
LTP
1.00
 - -
0.78
 --
S 307 VGLTRRSRTESITATSPASMV - 15199052
LTP
1.00
 - -
0.78
 --
S 307 VGLTRRSRTESITATSPASMV - 16129690
LTP
1.00
 - -
0.78
 --
S 312 RSRTESITATSPASMVGGKPG IKK_group 12351658
LTP
1.00
 - -
0.80
 --
S 312 RSRTESITATSPASMVGGKPG - 11606564
LTP
1.00
 - -
0.80
 --
S 312 RSRTESITATSPASMVGGKPG - 15199052
LTP
1.00
 - -
0.80
 --
S 323 PASMVGGKPGSFRVRASSDGE PKC_zeta 15516986
LTP
0.05
 - -
0.79
 --
S 323 PASMVGGKPGSFRVRASSDGE - 14583092
LTP
0.05
 - -
0.79
 --
S 323 PASMVGGKPGSFRVRASSDGE PKC_zeta 16129678
LTP
0.05
 - -
0.79
 --
S 341 DGEGTMSRPASVDGSPVSPST IKK_group 12351658
LTP
0.96
 - -
0.90
 --
S 345 TMSRPASVDGSPVSPSTNRTH IKK_group 12351658
LTP
1.00
 - -
0.90
 --
S 348 RPASVDGSPVSPSTNRTHAHR - 16020478
LTP
1.00
 - -
0.90
 --
S 348 RPASVDGSPVSPSTNRTHAHR - 18220336
HTP
1.00
 - -
0.90
 --
S 374 RLHPPLNHSRSIPMPASRCSP - 16020478
LTP
1.00
 YWHAG 14-3-3;
YWHAZ 14-3-3		 -
0.77
 --
S 527 LDNRFRKRTHSAGTSPTITHQ IKK_group 12351658
LTP
1.00
 - -
0.82
 --
T 530 RFRKRTHSAGTSPTITHQKTP - 16020478
LTP
1.00
 - -
0.88
 --
S 531 FRKRTHSAGTSPTITHQKTPS IKK_group 12351658
LTP
1.00
 - -
0.89
 --
S 531 FRKRTHSAGTSPTITHQKTPS - 18220336
HTP
1.00
 - -
0.89
 --
S 574 SGGRLPGHRHSAFVPTRSYPE PKC_delta 15516986
LTP
1.00
 - -
0.80
 --
S 574 SGGRLPGHRHSAFVPTRSYPE - 14583092
LTP
1.00
 - -
0.80
 --
Y 612 DSSTLHTDDGYMPMSPGVAPV - 15001544
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.81
 --
Y 612 DSSTLHTDDGYMPMSPGVAPV - 18083107
HTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.81
 --
S 616 LHTDDGYMPMSPGVAPVPSGR MAPK3 15001544
LTP
0.18
 MOD_ProDKin_1
 - -
0.82
 --
S 616 LHTDDGYMPMSPGVAPVPSGR - 14769130
LTP
0.18
 MOD_ProDKin_1
 - -
0.82
 --
S 629 VAPVPSGRKGSGDYMPMSPKS - 17081983
HTP
0.30
 - -
0.82
 --
Y 632 VPSGRKGSGDYMPMSPKSVSA - 15001544
LTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.83
 --
Y 632 VPSGRKGSGDYMPMSPKSVSA - 18083107
HTP
1.00
 PIK3R1 SH2;
PIK3R2 SH2		 -
0.83
 --
S 636 RKGSGDYMPMSPKSVSAPQQI - 14769130
LTP
1.00
 - -
0.79
 --
S 636 RKGSGDYMPMSPKSVSAPQQI - 16099428
LTP
1.00
 - -
0.79
 --
S 636 RKGSGDYMPMSPKSVSAPQQI - 15576463
LTP
1.00
 - -
0.79
 --
S 636 RKGSGDYMPMSPKSVSAPQQI - 16123357
LTP
1.00
 - -
0.79
 --
S 636 RKGSGDYMPMSPKSVSAPQQI - 17081983
HTP
1.00
 - -
0.79
 --
S 639 SGDYMPMSPKSVSAPQQIINP - 14769130
LTP
1.00
 - -
0.73
 --
S 639 SGDYMPMSPKSVSAPQQIINP - 16099428
LTP
1.00
 - -
0.73
 --
S 639 SGDYMPMSPKSVSAPQQIINP - 15576463
LTP
1.00
 - -
0.73
 --
S 639 SGDYMPMSPKSVSAPQQIINP - 16123357
LTP
1.00
 - -
0.73
 --
Y 662 RHPQRVDPNGYMMMSPSGGCS - 15592455
HTP
1.00
 Fyn SH2;
MATK SH2;
PIK3R1 SH2;
PTPN11 SH2		 -
0.77
 --
S 794 ARHQHLRLSTSSGRLLYAATA SIK 12624099
LTP
1.00
 - -
0.65
 --
S 794 ARHQHLRLSTSSGRLLYAATA AMPK_group 20135346
LTP
1.00
 - -
0.65
 --
S 892 QPLLHPPEPKSPGEYVNIEFG - 16020478
LTP
1.00
 - -
0.79
 --
Y 896 HPPEPKSPGEYVNIEFGSDQS - 11259577
LTP
1.00
 GRB2 SH2;
PTPN11 SH2		 -
0.76
 --
S 1078 GMSAFTRVNLSPNRNQSAKVI - 16503154
LTP
0.30
 - -
0.60
 --
S 1101 DPQGCRRRHSSETFSSTPSAT PKC_theta 15364919
LTP
1.00
 - -
0.78
 --
S 1101 DPQGCRRRHSSETFSSTPSAT - 17081983
HTP
1.00
 - -
0.78
 --
S 1101 DPQGCRRRHSSETFSSTPSAT RSK-1 17709744
LTP
1.00
 - -
0.78
 --
S 1101 DPQGCRRRHSSETFSSTPSAT - 18220336
HTP
1.00
 - -
0.78
 --
T 1111 SETFSSTPSATRVGNTVPFGA - 18220336
HTP
1.00
 - -
0.68
 --
S 1145 SEDVKRHSSASFENVWLRPGE - 16020478
LTP
1.00
 - -
0.61
 --
S 1222 GSGESSSTRRSSEDLSAYASI - 16020478
LTP
0.07
 - -
0.70
 --
S 1223 SGESSSTRRSSEDLSAYASIS - 16020478
LTP
0.11
 - -
0.68
 --

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35569 [Mus musculus]
Download:fasta csv
Interaction Network(s): -
External Source(s): PhosidaPhosida
MINT Interaction(s):
[show]
MINT-58476   NUCL_MOUSE
MINT-6381887   P85A_MOUSE
MINT-6793439   PTN1_HUMAN
MINT-6794075   INSR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
insulin-like growth factor receptor binding,
insulin receptor binding,
SH2 domain binding		 microsome,
cytosol,
nucleus		 positive regulation of mesenchymal cell proliferation,
positive regulation of cell migration,
protein kinase B signaling cascade,
mammary gland development,
insulin receptor signaling pathway
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 3         MASPPDTDGFSDV - 17242355
HTP
 - - -
0.50
 --
S 267 DEFRPRSKSQSSSSCSNPISV - 12714600
LTP
1.00
 - -
0.66
 --
S 302 VGLTRRSRTESITATSPASMV PKB_group 11701324
LTP
1.00
 MOD_PKB_1
 - -
0.78
 --
S 307 RSRTESITATSPASMVGGKPG - 16055440
LTP
1.00
 - -
0.80
 --
S 307 RSRTESITATSPASMVGGKPG - 15994203
LTP
1.00
 - -
0.80
 --
S 307 RSRTESITATSPASMVGGKPG - 12714600
LTP
1.00
 - -
0.80
 --
S 307 RSRTESITATSPASMVGGKPG - 14998989
LTP
1.00
 - -
0.80
 --
S 307 RSRTESITATSPASMVGGKPG - 11160134
LTP
1.00
 - -
0.80
 --
S 307 RSRTESITATSPASMVGGKPG - 15314024
LTP
1.00
 - -
0.80
 --
S 318 PASMVGGKPGSFRVRASSDGE PKC_group 16129678
LTP
0.05
 - -
0.79
 --
S 318 PASMVGGKPGSFRVRASSDGE PKC_group 16099431
LTP
0.05
 - -
0.79
 --
S 318 PASMVGGKPGSFRVRASSDGE PKC_group 16055440
LTP
0.05
 - -
0.79
 --
S 324 GKPGSFRVRASSDGEGTMSRP - 17242355
HTP
1.00
 - -
0.83
 --
S 340 TMSRPASVDGSPVSPSTNRTH - 17242355
HTP
1.00
 - -
0.90
 --
S 408 TSDCLFPRRSSASVSGSPSDG - 15485932
LTP
1.00
 - -
0.60
 --
Y 608 DTSNLHTDDGYMPMSPGVAPV - 9395471
LTP
1.00
 PIK3R1 SH2 -
0.80
 --
Y 608 DTSNLHTDDGYMPMSPGVAPV - 15821749
LTP
1.00
 PIK3R1 SH2 -
0.80
 --
S 612 LHTDDGYMPMSPGVAPVPSNR - 15994203
LTP
0.18
 - -
0.81
 --
S 612 LHTDDGYMPMSPGVAPVPSNR - 9395471
LTP
0.18
 - -
0.81
 --
S 612 LHTDDGYMPMSPGVAPVPSNR - 15821749
LTP
0.18
 - -
0.81
 --
S 612 LHTDDGYMPMSPGVAPVPSNR - 10092613
LTP
0.18
 - -
0.81
 --
S 632 RKGNGDYMPMSPKSVSAPQQI ROCK2 16098829
LTP
1.00
 - -
0.79
 --
S 632 RKGNGDYMPMSPKSVSAPQQI - 11287630
LTP
1.00
 - -
0.79
 --
S 635 NGDYMPMSPKSVSAPQQIINP ROCK2 16098829
LTP
1.00
 - -
0.72
 --
S 635 NGDYMPMSPKSVSAPQQIINP - 11287630
LTP
1.00
 - -
0.72
 --
S 635 NGDYMPMSPKSVSAPQQIINP - 15994203
LTP
1.00
 - -
0.72
 --
S 789 ARHQHLRLSSSSGRLRYTATA AMPK_group 11598104
LTP
0.03
 - -
0.75
 --
S 1097 DTQGCRRRHSSETFSAPTRAG - 15364919
LTP
1.00
 - -
0.79
 --
S 1139 SEDVKRHSSASFENVWLRPGD - 17242355
HTP
1.00
 - -
0.64
 --
S 1214 SNEGNSPRRSSEDLSNYASIS - 17242355
HTP
1.00
 - -
0.76
 --

Substrate: Insulin receptor substrate 1 (After phosphorylation by insulin receptor binds to various cellular proteins containing SH2 domains.)
Seq-ID: P35570 [Rattus norvegicus]
Download:fasta csv
Interaction Network(s): -
External Source(s): Phosida
MINT Interaction(s):
[show]
MINT-45938   ITB2_HUMAN
MINT-45939   ITB3_HUMAN
MINT-60761   INSR_RAT
MINT-6762786   GRB2_HUMAN
MINT-6762811   PTN11_HUMAN
MINT-6762830   PTPRA_HUMAN
MINT-6762866   PTN1_HUMAN
MINT-6762880   P85A_HUMAN
MINT-6762904   CRK_HUMAN
MINT-6795115   INSR_HUMAN
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
phosphoinositide 3-kinase binding,
protein kinase C binding,
insulin-like growth factor receptor binding,
insulin-like growth factor receptor activity,
insulin receptor binding,
transmembrane receptor protein tyrosine kinase docking protein activity,
SH2 domain binding		 microsome,
cytosol,
insulin receptor complex,
nucleus		 negative regulation of insulin receptor signaling pathway,
negative regulation of somatostatin secretion,
positive regulation of insulin receptor signaling pathway,
negative regulation of insulin secretion,
protein heterooligomerization,
insulin receptor signaling pathway,
positive regulation of phosphoinositide 3-kinase activity,
positive regulation of phosphorylation,
positive regulation of glucagon secretion
Conservation:
Click on table headers for sorting
Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 99 RDEHFAIAADSEAEQDSWYQA CK2_group 8349691
LTP
0.11
 MOD_CK2_1
 - PH
0.28
 - medium
Y 460 PARGEEELSNYICMGGKGAST INSR 7504175
LTP
1.00
 - -
0.58
 - medium
T 502 GATMGTSPALTGDEAAGAADL CK2_group 8349691
LTP
0.00
 MOD_CK2_1
 - -
0.72
 - medium
Y 608 DSSNLHTDDGYMPMSPGVAPV INSR 7504175
LTP
1.00
 PIK3R1 SH2 -
0.79
 - medium
Y 608 DSSNLHTDDGYMPMSPGVAPV - 12220227
LTP
1.00
 PIK3R1 SH2 -
0.79
 - medium
Y 608 DSSNLHTDDGYMPMSPGVAPV IGF1R 11572799
LTP
1.00
 PIK3R1 SH2 -
0.79
 - medium
Y 608 DSSNLHTDDGYMPMSPGVAPV INSR 11572799
LTP
1.00
 PIK3R1 SH2 -
0.79
 - medium
Y 628 VPSNRKGNGDYMPMSPKSVSA INSR 7504175
LTP
1.00
 PIK3R1 SH2 -
0.81
 - medium
Y 628 VPSNRKGNGDYMPMSPKSVSA IGF1R 11572799
LTP
1.00
 PIK3R1 SH2 -
0.81
 - medium
Y 628 VPSNRKGNGDYMPMSPKSVSA INSR 11572799
LTP
1.00
 PIK3R1 SH2 -
0.81
 - medium
Y 658 RHPQRVDPNGYMMMSPSGSCS IGF1R 11572799
LTP
1.00
 - -
0.72
 - medium
Y 727 GGKLLPCTGDYMNMSPVGDSN IGF1R 11572799
LTP
1.00
 - -
0.60
 - medium
S 789 ARHQHLRLSSSSGRLRYTATA AMPK_group 11598104
LTP
0.03
 - -
0.77
 - medium
Y 895 HPPEPKSPGEYVNIEFGSGQP INSR 7504175
LTP
1.00
 GRB2 SH2 -
0.80
 - medium
Y 895 HPPEPKSPGEYVNIEFGSGQP IGF1R 8530377
LTP
1.00
 GRB2 SH2 -
0.80
 - medium
Y 895 HPPEPKSPGEYVNIEFGSGQP INSR 8530377
LTP
1.00
 GRB2 SH2 -
0.80
 - medium
Y 939 APREETGSEEYMNMDLGPGRR INSR 7504175
LTP
1.00
 PIK3R1 SH2 -
0.87
 - medium
Y 939 APREETGSEEYMNMDLGPGRR IGF1R 11572799
LTP
1.00
 PIK3R1 SH2 -
0.87
 - medium
Y 939 APREETGSEEYMNMDLGPGRR INSR 11572799
LTP
1.00
 PIK3R1 SH2 -
0.87
 - medium
Y 987 TRSVPNSRGDYMTMQIGCPRQ INSR 7504175
LTP
0.16
 - -
0.64
 - medium
Y 987 TRSVPNSRGDYMTMQIGCPRQ IGF1R 11572799
LTP
0.16
 - -
0.64
 - medium
Y 987 TRSVPNSRGDYMTMQIGCPRQ INSR 11572799
LTP
0.16
 - -
0.64
 - medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK INSR 7504175
LTP
1.00
 PTPN11 SH2 -
0.48
 - medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK IGF1R 11572799
LTP
1.00
 PTPN11 SH2 -
0.48
 - medium
Y 1172 AAGGLEKSLNYIDLDLVKDVK INSR 11572799
LTP
1.00
 PTPN11 SH2 -
0.48
 - medium
Y 1222 PRRSSEDLSTYASINFQKQPE INSR 7504175
LTP
0.09
 PTPN11 SH2 -
0.77
 - medium
Y 1222 PRRSSEDLSTYASINFQKQPE - 12220227
LTP
0.09
 PTPN11 SH2 -
0.77
 - medium

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